Old 02-21-2020, 10:50   #196
Trapper John
Quiet Professional
 
Trapper John's Avatar
 
Join Date: Nov 2012
Location: Harrisburg, PA
Posts: 3,533
https://www.cell.com/cell/fulltext/S...674(20)30103-3

Click on the NK cell maturation graphic so you can watch the video and don't have to read Carl.

OK youse guys, gather around and take a knee. Smoke 'em if you got 'em!

The problem with this whole pandemic think issue is the absence of adequate medical counter-measures! Why is that you ask? Excellent question, Carl.

Every time a new antibiotic resistant bacterium emerges we go into a full-blown panic to develop a new antibiotic. Same with a new virus with pandemic potential. Rush to develop a new vaccine- e.g. the excitement surrounding the newly discovered "spike protein on the virus.

I call this the "see bug- kill bug approach. So what's wrong with that? Sit down Carl and pay attention. Overuse and misuse of antibiotics induces antibiotic resistance. So developing new antibiotics to combat antibiotic resistant bacteria is merely repeating the same experiment while expecting a different outcome.

Humans have been confronted with these challenges over millions of years of evolution and yet here we are. The better question is what are the natural defense mechanisms and how can they be pharmaceutically exploited to provide resistance?

Vaccine development is one strategy. Exploiting the innate arm of the immune response (see link provided above) is another. We are still in the infancy of being able to fully exploit this strategy. I published a paper in 2012 that is the first such attempt. We are continuing to push the envelope on this. [NLRP3 Inflammasome is a Target for Development of Broad-Spectrum Anti-Infective Drugs Antimicrob. Agents Chemother. 2012, 56(4):1921. Carol M. Artlett, Sihem Sassi-Gaha, Mitali Purohit, Richard F. Rest and James D. Thacker]
__________________
Honor Above All Else

Last edited by Trapper John; 02-21-2020 at 11:51.
Trapper John is offline   Reply With Quote
Old 02-21-2020, 11:48   #197
InTheBlack
BANNED USER
 
Join Date: May 2006
Posts: 249
Quote:
Originally Posted by T-Rock View Post
One study that I've read shows that by September 2020, ( https://www.medrxiv.org/content/10.1...VgdiEesYBsnER8 )
This Virus will be totally global with an RO of nearly 6.6
I can't find that bit; "september" is not in the document.
InTheBlack is offline   Reply With Quote
Old 02-21-2020, 16:14   #198
InTheBlack
BANNED USER
 
Join Date: May 2006
Posts: 249
Remember when parents had "measles parties" to make sure that their kid got the measles done with, so it didn't infect them later as an adult? Maybe we should be culturing the virus from people who don't show symptoms...

https://www.medscape.com/viewarticle...=2286507&faf=1

Silent COVID-19 Cases May Stymie Screening Efforts
Brenda Goodman
February 20, 2020

snip
The researchers tested 126 people who were returning to Germany after recent travel from China. On the flight, 10 people were isolated because they were at high risk of being infected — some had symptoms, and others had contact with people who were infected.

As soon as the plane touched down, these 10 passengers were taken to a hospital and tested for the virus. None were positive.

Doctors examined the rest of the passengers at a medical assessment center at the airport. One passenger had a fever, a hard time breathing, and a cough. He was also tested, and was negative for the virus.

In a last step, researchers offered testing to the remaining 115 people who were on board the plane and who had passed their screening checks.

In a surprise twist, two of these seemingly healthy passengers tested positive for the virus. Two different labs confirmed their test results.

The passengers who tested positive were whisked to a hospital, where an exam showed that one had a very slight sore throat and a faint rash. Both remained well and never ran a fever in the week after they were admitted to the hospital.

More worrisome, when the virus that was isolated from the two passengers was placed in a test tube with healthy cells, it was able to infect them. That means it's possible they could have passed the disease on to others, even when they had few to no symptoms themselves.

"We do not yet know if they could have infected other people, but that is conceivable," says Sandra Ciesek, MD, head of the Institute of Medical Virology at the University Hospital Frankfurt. She says there's no evidence that they did.
snip

The New England Journal of Medicine: "Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China."

Last edited by InTheBlack; 02-21-2020 at 16:17.
InTheBlack is offline   Reply With Quote
Old 02-22-2020, 00:46   #199
T-Rock
BANNED USER
 
Join Date: Aug 2009
Location: Western NC
Posts: 1,243
I thought we only had 34 cases? Now there's 70?

"Costa Mesa Seeks To Block Transfer Of Up To 70 Coronavirus Patients To City"

According to the story they're "California residents."

> https://www.google.com/amp/s/losange...ronavirus/amp/

Last edited by T-Rock; 02-22-2020 at 01:26.
T-Rock is offline   Reply With Quote
Old 02-22-2020, 06:13   #200
Badger52
Area Commander
 
Join Date: Jan 2011
Location: Western WI
Posts: 5,211
Quote:
Originally Posted by InTheBlack View Post
In a last step, researchers offered testing to the remaining 115 people who were on board the plane and who had passed their screening checks.

In a surprise twist, two of these seemingly healthy passengers tested positive for the virus. Two different labs confirmed their test results. [So, in other words, testing for asymptomatic persons remains optional? - in the face of evidence that the practice misses the mark.]

The passengers who tested positive were whisked to a hospital, where an exam showed that one had a very slight sore throat and a faint rash. Both remained well and never ran a fever in the week after they were admitted to the hospital.

More worrisome, when the virus that was isolated from the two passengers was placed in a test tube with healthy cells, it was able to infect them. That means it's possible they could have passed the disease on to others, even when they had few to no symptoms themselves.

"We do not yet know if they could have infected other people, but that is conceivable," says Sandra Ciesek, MD, head of the Institute of Medical Virology at the University Hospital Frankfurt. She says there's no evidence that they did. [And you know this because you've been following up everyone they're in contact with?]
Heh. What's the criteria for determining if learning is taking place again...?
__________________
"Civil Wars don't start when a few guys hunt down a specific bastard. Civil Wars start when many guys hunt down the nearest bastards."

The coin paid to enforce words on parchment is blood; tyrants will not be stopped with anything less dear. - QP Peregrino
Badger52 is offline   Reply With Quote
Old 02-22-2020, 08:16   #201
T-Rock
BANNED USER
 
Join Date: Aug 2009
Location: Western NC
Posts: 1,243
Asymptomatic transmission up to 27 days.....???? Nothing to see? Really?

https://www.usnews.com/news/world/ar...overnment-says

https://m.theepochtimes.com/growing-...f_3246071.html

Last edited by T-Rock; 02-22-2020 at 08:28.
T-Rock is offline   Reply With Quote
Old 02-23-2020, 00:05   #202
TOMAHAWK9521
Quiet Professional
 
TOMAHAWK9521's Avatar
 
Join Date: May 2008
Location: Idaho
Posts: 1,087
I was looking up N95 masks a week ago on Amazon and found a set of 2 packs of 10 3M Aura Particulate Disposable Respirator 9211, NIOSH for roughly $55.00 IIRC. As a guy who is always tinkering in the sorcerer's laboratory, those would fit much nicer than the usual clam shell models. However, since this virus is spreading I thought I might go back and move said masks from my "wish list" into my checkout basket. When I clicked on my list this evening, they were listed as "sold out"/"don't know when they'll be available.

I was a bit stunned so I poked around for similar products and clicked on an exact copy of the set from another listing. It read, "See buying options". Click on the button and they're now listed for $185.00. Guess I should have seen that coming.

Other similar products are rated all over the place. 3M are usually listed high while others are criticized as being crap.
__________________
"It is a brave act of valor to condemn death, but where life is more terrible than death, it is then the truest valor to dare to live." -Sir Thomas Browne (1605-1682)
TOMAHAWK9521 is offline   Reply With Quote
Old 02-23-2020, 01:05   #203
T-Rock
BANNED USER
 
Join Date: Aug 2009
Location: Western NC
Posts: 1,243
We're remodeling at our place so while at Lowe's this past week, my wife and I decided to take a stroll down the respirator isle just to see what their inventory was like. The young gentleman stocking on the same isle saw us looking at 2 of the 3M N100/P100 safety masks. He told us if you want those you might wanna go ahead and purchase them, because a group came in earlier and purchased 100 of those masks, all our replacement filters, and those 2 are the only ones we have left at our location. Get em' while you can.
T-Rock is offline   Reply With Quote
Old 02-23-2020, 11:11   #204
SF_BHT
Quiet Professional
 
SF_BHT's Avatar
 
Join Date: Jun 2007
Location: Sneaking back and forth across the Border
Posts: 6,441
I stock those mask at my office and usually have 100+/- on hand always. I was questioned by my HQ with some other office how many I had and they asked all of us to ship them to the HQ warehouse.

Hummmm

Sorry to say I only had 2 on hand when they sent the request

I just renewed our normal order and it will be 3 months before the order is filled.

Guess you had better buy them when you can find them......
SF_BHT is offline   Reply With Quote
Old 02-23-2020, 20:55   #205
Badger52
Area Commander
 
Join Date: Jan 2011
Location: Western WI
Posts: 5,211
Quote:
Originally Posted by SF_BHT View Post
Sorry to say I only had 2 on hand when they sent the request
Yeah, I'd have been "fresh out" of cross-levelling stock for them as well maybe.
__________________
"Civil Wars don't start when a few guys hunt down a specific bastard. Civil Wars start when many guys hunt down the nearest bastards."

The coin paid to enforce words on parchment is blood; tyrants will not be stopped with anything less dear. - QP Peregrino
Badger52 is offline   Reply With Quote
Old 02-24-2020, 19:39   #206
frostfire
Area Commander
 
frostfire's Avatar
 
Join Date: Nov 2004
Location: land of Airborne and Special Operations
Posts: 2,035
Quote:
Originally Posted by SF_BHT View Post
I stock those mask at my office and usually have 100+/- on hand always. I was questioned by my HQ with some other office how many I had and they asked all of us to ship them to the HQ warehouse.

Hummmm

Sorry to say I only had 2 on hand when they sent the request

I just renewed our normal order and it will be 3 months before the order is filled.

Guess you had better buy them when you can find them......
We are hoarding them at embassy no matter where the requests come from.
The supply has been designed for true SHTF pandemic!
On a related note.... the stock market... ouch 😣 !!!
__________________
"we also rejoice in our sufferings, because we know that suffering produces perseverance; perseverance, character; and character, hope" Rom. 5:3-4

"So we can suffer, and in suffering we know who we are" David Goggins

"Aide-toi, Dieu t'aidera " Jehanne, la Pucelle

Der, der Geld verliert, verliert einiges;
Der, der einen Freund verliert, verliert viel mehr;
Der, der das Vertrauen verliert, verliert alles.

INDNJC
frostfire is offline   Reply With Quote
Old 02-24-2020, 20:55   #207
PSM
Area Commander
 
PSM's Avatar
 
Join Date: Nov 2005
Location: Cochise Co., AZ
Posts: 5,789
Quote:
Originally Posted by frostfire View Post

On a related note.... the stock market... ouch �� !!!
It's a big number, but a small percentage. Don't fall for that. Plus, if you have a 401(k) you are buying in cheaply now. It hurts retirees because they don't usually have more money to invest but, if it was managed correctly, they should be fine. We are and we're fine. (We "lost" the equivalent of a Chevy Suburban today, though. )
__________________
"Hector Lives!"

"The limits of tyrants are prescribed by the endurance of those whom they oppress." -- Frederick Douglass

"The bigger the government, the smaller the citizen." -- Dennis Prager

"The urge to save humanity is almost always only a false-face for the urge to rule it." --H.L. Mencken

Last edited by PSM; 02-24-2020 at 20:58.
PSM is offline   Reply With Quote
Old 02-25-2020, 09:30   #208
T-Rock
BANNED USER
 
Join Date: Aug 2009
Location: Western NC
Posts: 1,243
14.8% of confirmed cases among Health Care workers were classified as severe or critical.
From JAMA:
https://jamanetwork.com/journals/jam...rticle/2762130
T-Rock is offline   Reply With Quote
Old 02-25-2020, 12:29   #209
mugwump
Area Commander
 
Join Date: Nov 2005
Posts: 1,403
Quote:
Originally Posted by PSM View Post
It's a big number, but a small percentage. Don't fall for that. Plus, if you have a 401(k) you are buying in cheaply now. It hurts retirees because they don't usually have more money to invest but, if it was managed correctly, they should be fine. We are and we're fine. (We "lost" the equivalent of a Chevy Suburban today, though. )
Wait until the true magnitude sinks in. They’re out of several critical abx at my daughter's shop, a major state health magnet, and are told no resupply is in sight.

A corner was turned last Friday. All major epidemiologist and the CDC have said containment is impossible, expect a major outbreak in the US.

And do you know how many COVID19 diagnostic tests were processed in the last ten days in the US? Sixteen per day. Sixteen. That’s all CDC can do. No surge capacity either. They’re stretched at 16. South Korea has been averaging 1700 tests per day and can handle 4000/day surge.

Every once in a while a legitimate crisis reveals how corrupt things have gotten. We're there.
__________________
mugwump

“Klaatu barada nikto”
mugwump is offline   Reply With Quote
Old 02-25-2020, 12:39   #210
mugwump
Area Commander
 
Join Date: Nov 2005
Posts: 1,403
The twitterverse is abuzz with news of harsh Chinese crackdowns and the arrests of crematoria managers who yesterday reported that death figures were total fiction. They said each of 15 crematoriums have been processing 100 corpses per day, were running 24/7 for the last two weeks, and the equipment was breaking down and they can’t get spare parts.

Doctors and crematoria staff have been told any discussion of deaths will result in severe punishment.

There are reports, with pics, that 40 portable industrial incinerators have been emplaced in Wuhan that can process 5 tons/day each. The regime says to destroy medical waste.

Buckle up.
__________________
mugwump

“Klaatu barada nikto”
mugwump is offline   Reply With Quote
Reply


Currently Active Users Viewing This Thread: 2 (1 members and 1 guests)
Airbornelawyer
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off

Forum Jump



All times are GMT -6. The time now is 00:40.



Copyright 2004-2019 by Professional Soldiers ®
Site Designed, Maintained, & Hosted by Hilliker Technologies